The Role of Interferon Regulatory Factors in Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular diseases. steatohepatitis (NASH), an advanced form of NAFLD, accompanies progression hepatic steatosis, inflammation, cell death, varying degree fibrosis. Interferons (IFNs) have been shown to play important roles in pathogenesis NAFLD NASH. Their regulating transcriptional factors interferon regulatory (IRFs) can regulate IFN expression, well genes involved macrophage polarization, which are implicated disease. In this review, IRF-involved signaling pathways insulin resistance, immune activation reviewed. IRFs IRF1 IRF4 also polarization macrophages that contribute critical or NASH pathogenesis. addition, be regulated by treatments including microRNAs, PPAR modulators, anti-inflammatory agents, TLR agonists antagonists. Modulating IRF-mediated through these ameliorate Furthermore, adenoviruses CRISPR plasmids applied effects Pre-clinical clinical trials for evaluating IRF regulators treatment essential future direction.